uhplc-esi-ms/ms and gc-ms analyses on phenolic, fatty acid and essential oil of verbascum pinetorum with antioxidant, anticholinesterase, antimicrobial and dna damage protection effects

نویسندگان

mehmet boğa dicle university

abdulselam ertas dicle university

mustafa abdullah yılmaz dicle university

murat kızıl department of chemistry, faculty of science and arts, dicle university

چکیده

this paper is the first phytochemical and abts cation radical decolorisation activity, cupric reducing antioxidant capacity, anticholinesterase and dna damage protection effect of endemic verbascum pinetorum (boiss.) o. kuntze. phenolic profile of v. pinetorum were qualified and quantified by uhplc-esi-ms/ms analysis. malic acid (47250.61±2504.28 µg/g) and luteolin (7651.96±527.98 µg/g) were found as most abundant compounds for metanol and acetone extracts, respectively. fatty acid and essential oil compositions were determined by gc-ms analysis. the main components of fatty acid were found to be palmitic (27.1%) and stearic (22.1%) acids. the main compounds of the essential oil were cineole (16.9%) and α-selinene (16.4%). the acetone extract was found to be more active than bht used as a standard in β-carotene-linoleic acid test system. in dpph free radical scavenging activity, the acetone and methanol extracts showed higher activity than bht at all tested concentrations. the acetone, methanol and water extracts showed strong inhibition while the acetone extract showed better activity than bht and α-tocopherol which were used as standards in abts cation radical scavenging and cupric reducing antioxidant capacity assays, respectively. all extracts were found to be inactive in antialzheimer activity. the acetone extract exhibited moderate antimicrobial activity against c. albicans. the methanol extract of v. pinetorum were found no significant effect on dna cleavage protection.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

UHPLC-ESI-MS/MS and GC-MS Analyses on Phenolic, Fatty Acid and Essential Oil of Verbascum pinetorum with Antioxidant, Anticholinesterase, Antimicrobial and DNA Damage Protection Effects

This paper is the first phytochemical and ABTS cation radical decolorisation activity, cupric reducing antioxidant capacity, anticholinesterase and DNA damage protection effect of endemic Verbascum pinetorum (Boiss.) O. Kuntze. Phenolic profile of V. pinetorum were qualified and quantified by UHPLC-ESI-MS/MS analysis. Malic acid (47250.61±2504.28 µg/g) and luteolin (7651.96±527.98 µg/g) were fo...

متن کامل

UHPLC-ESI-MS/MS and GC-MS Analyses on Phenolic, Fatty Acid and Essential Oil of Verbascum pinetorum with Antioxidant, Anticholinesterase, Antimicrobial and DNA Damage Protection Effects

This paper is the first phytochemical and ABTS cation radical decolorisation activity, cupric reducing antioxidant capacity, anticholinesterase and DNA damage protection effect of endemic Verbascum pinetorum (Boiss.) O. Kuntze. Phenolic profile of V. pinetorum were qualified and quantified by UHPLC-ESI-MS/MS analysis. Malic acid (47250.61±2504.28 µg/g) and luteolin (7651.96±527.98 µg/g) were fo...

متن کامل

UHPLC-ESI-MS/MS and GC-MS Analyses on Phenolic, Fatty Acid and Essential Oil of Verbascum pinetorum with Antioxidant, Anticholinesterase, Antimicrobial and DNA Damage Protection Effects

This paper is the first phytochemical and ABTS cation radical decolorisation activity, cupric reducing antioxidant capacity, anticholinesterase and DNA damage protection effect of endemic Verbascum pinetorum (Boiss.) O. Kuntze. Phenolic profile of V. pinetorum were qualified and quantified by UHPLC-ESI-MS/MS analysis. Malic acid (47250.61±2504.28 µg/g) and luteolin (7651.96±527.98 µg/g) were fo...

متن کامل

Fatty Acid and Essential Oil Compositions of Trifolium angustifolium var. angustifolium with Antioxidant, Anticholinesterase and Antimicrobial Activities

This study represents the first report on the chemical composition and biological activity of Trifolium angustifolium var. angustifolium. The major components of the essential oil were identified as hexatriacontene (23.0%), arachidic acid (15.5%) and α-selinene (10.0%). The main constituents of the fatty acid obtained from the petroleum ether extract were identified as palmitic acid (29.8%), li...

متن کامل

Fatty Acid and Essential Oil Compositions of Trifolium angustifolium var. angustifolium with Antioxidant, Anticholinesterase and Antimicrobial Activities

This study represents the first report on the chemical composition and biological activity of Trifolium angustifolium var. angustifolium. The major components of the essential oil were identified as hexatriacontene (23.0%), arachidic acid (15.5%) and α-selinene (10.0%). The main constituents of the fatty acid obtained from the petroleum ether extract were identified as palmitic acid (29.8%), li...

متن کامل

antioxidant and antimicrobial activity of allium jesdianum extract

چکیده بررسی فعالیت ضد اکسیدانی و ضدمیکروبی عصاره گیاه بن سرخ (allium jesdianum) به کوشش: زهرا مقیمی هدف از این تحقیق بررسی میزان ترکیبات فنولی کل، ترکیبات فلاوونوئیدی کل، فعالیت ضداکسیدانی و ضدمیکروبی عصاره ی گیاه تازه و خشک بن سرخ بود. استخراج عصاره به روش های غوطه وری، استفاده از همزن مغناطیسی، دستگاه مایکروویو، امواج فراصوت و گرمادهی مقاومتی و با استفاده از متانول، اتانول و آب به عنوا...

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
the iranian journal of pharmaceutical research

جلد ۱۵، شماره ۳، صفحات ۳۹۳-۴۰۵

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023